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Compared with Ki-67 expression and detection of high-risk human papillomavirus, p16(INK4a) was less likely to be positive in samples from women with negative, reactive, and atypical biopsies. Although expression of p16(INK4a) in endometrial epithelium may be problematic in terms of screening, the potential of p16(INK4a) as a screening test warrants investigation. Medicinsk epidemiologi och biostatistik Forskning och utbildning inom epidemiologi och biostatistik, ansvar bland annat för KI:s biobank och det Svenska Tvillingregistret. Mikrobiologi, tumör- och cellbiologi Bedriver forskning inom immunologi, infektion och cancer.

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Despite studies showing its phosphorylation, arginine methylation, and interaction with several regulatory proteins, the functional role of Ki-1/57 in human cells remains to be determined. The cut-off limits obtained for Ki-67-Average (IHC) were TC-AC 1.5, AC-SCLC 19, and AC-LCNEC 23.5. The Hotspot evaluation generated equal to higher, the digital image analysis generally lower between-entity cut-off limits.All three markers enabled a clear-cut differentiation between the BP-NEN entities, and all methods evaluated were suitable Ki-67 is an antigen of cellular proliferation. Immunohistochemical staining for Ki-67 in archival material can be performed using the MIB-1 antibody. Unlike our results with p53 and bcl-2, Ki-67 protein expression by immunohistochemistry using MIB-1 was not an independent prognostic marker for cancer recurrence after radical prostatectomy As a cell proliferation biomarker, Ki-67 is principally used in ER+/HER2− breast cancer. However, the importance and the best cutoff point of Ki-67 in triple-negative breast cancer (TNBC Ki-67 is a nuclear antigen expressed by all proliferating cells during late G1 through the M phases of the cell cycle, peaking in the G2-M and with a rapid decline after mitosis [ 1 ]. Ki-67 labeling index assessed by immunohistochemical assays is a powerful prognostic marker in breast cancer.

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Like. För någon vecka sedan fick den största medicinska databasen Pubmed ett nytt utseende och gränssnitt.

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Affiliation 1 Department of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK. PubMed Central® (PMC) is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM). As from 12 January 2021 KI has an updated policy regarding publishing open access. The policy concerns all researchers at, or affiliated to, KI when publishing research results in publications. 2021-01-15 Nu har biblioteket i Solna infört meröppet för KI-studenter och KI-anställda. Biblioteket i Solna kommer vara meröppet alla dagar i veckan kl 7.00–22.00 med KI-kort. 2021-03-16 Both high Ki-67 expression and grade 3 tumours were independent predictors of inferior RFS in all patients, especially in those with luminal-like tumours (p < 0.05). Ki-67 was an independent prognostic factor for RFS in grade 1, 2 patients with luminal-like tumours (adjusted hazard ratio [HR] = 1.92, 95% confidence interval [CI]: 1.22-3.03, p = 0.005), but not in the other subtypes.
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Lägg till på hemskärmen så fungerar sidan som en app. Ki-67 expression in 103 primary breast carcinomas and their corresponding axillary lymph node metastases was correlated with age, tumor grade, size, estrogen receptor (ER), progesterone receptor (PgR), p53, epidermal growth factor receptor (EGFR), Bcl-2, Her-2 status, and patients' overall survival. Currently, acute allograft rejection can only be detected reliably by deterioration of graft function confirmed by allograft biopsy.

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På biblioteket. The cytoplasmic and nuclear protein Ki-1/57 was first identified in malignant cells from Hodgkin's lymphoma. Despite studies showing its phosphorylation, arginine methylation, and interaction with several regulatory proteins, the functional role of Ki-1/57 in human cells remains to be determined. The cut-off limits obtained for Ki-67-Average (IHC) were TC-AC 1.5, AC-SCLC 19, and AC-LCNEC 23.5.